Public Health
The University of Pittsburgh Medical Center (UPMC) recently became the first non-profit health care provider in the country to achieve an internationally recognized standard for effectiveness and efficiency in software development. Achievement of the Capability Maturity Model Integration (CMMI) Level 2 rating is based on a rigorous appraisal methodology from Carnegie Mellon University"s Software Engineering Institute.
Amsterdam Molecular Therapeutics (Euronext: AMT), a leader in the field of human gene therapy, announced that the European Medicines Agency has granted Orphan Drug Designation to AMT"s gene therapy product AMT-021 for the treatment of acute intermittent porphyria (AIP).
Though the growing shift toward oral chemotherapy agents offers cancer patients greater freedom and independence during their treatment, physicians say use of the new medications also poses more chances for patients to skip doses, miss prescription refills, and take their drugs in a dangerous way. An increasing number of cancer patients who receive chemotherapy now do so at home, with the click of a pill bottle each day rather than the drip of an IV medicine that must be delivered in a doctor"s office or hospital.
Cult skincare brand SKIN.NY(R) have issued legal proceedings against
Millions of Baby Boomers are struggling to care for their aging parents. Many don"t know where to turn or even what their options are in making important decisions about senior care facilities for their parents.
UnitedHealth Group"s Center for Health Reform and Modernization on Wednesday suggested 15 steps that could be taken to save $540 billion in federal in health care costs over the next 10 years, the AP/Seattle Post-Intelligencer reports (Werner, AP/Seattle Post-Intelligencer, 5/27). Simon Stevens, head of the center, said that the report "puts some flesh on the bones" of the pledge made by health care industry groups earlier this month to cut health care costs, noting that the recommendations already are being used by UnitedHealth to reduce costs and can be applied to Medicare (Reuters, 5/27).The recommended steps include:
A coalition of ethnic minority advocacy groups has raised concerns that two of six budget-related propositions on the May 19 special election ballot would negatively affect minorities" health, New America Media reports. Proposition 1A would increase California"s cash reserve from 3% to 12.5% of state revenue and create a state spending cap. The measure also would extend recent tax increases for an additional two years. Proposition 1D would shift funds from First 5 California Children and Families Program, which provides health care services to children regardless of their immigration status, to the general fund.Cary Sanders -- director of Having Our Say, a coalition of 50 Asian, Hispanic and black organizations -- said, "If Proposition 1A and 1D pass, communities of color will have to shoulder the cost of our broken system because Proposition 1A limits our ability to invest in the health care system and Proposition 1D will result in more children becoming uninsured." Sanders noted that the First 5 program could reduce health and educational disparities.Quyen Vuong, executive director of the International Children Assistance Network, said Prop. 1D would cut $1.6 billion from the First 5 program. Julie Soderlund of Budget Reform Now, a committee campaigning in favor of the ballot measures, rejected arguments that Prop. 1D would compromise children"s health services. She added that the First 5 program accumulates $400 million in state funds and $2.1 billion in county funds, which she said could be put to good use by diverting them to the general fund to support human services. Alice Chen, a board member of the California Pan-Ethnic Health Network, said Prop. 1A could restrict minority communities" access to immunizations and dental and health services. However, Soderlund said that Prop. 1A would help prevent "roller coaster rides" in the state"s budget. State Assembly member Fiona Ma (D), who also supports the measures, said she is concerned that if the propositions fail, lawmakers would have to pursue other alternatives to close the budget gap, which could have an even worse impact on communities.Jan Robinson-Flint, executive director of Black Women for Wellness, raised concern over the legislative power Prop. 1A gives the governor over spending for programs. She asked, "Do we trust our current and future governors to do what"s right for our communities?" (Po/Ng, New America Media, 5/13).
At least six states have considered eliminating or reducing financial assistance for those enrolled in the Medicare prescription drug benefit program who are affected by the "doughnut hole," or gap in coverage, the AP/Boston Herald reports. According to the AP/Herald, the governors of Rhode Island and Vermont and lawmakers in South Carolina have proposed plans to eliminate such financial assistance programs, while Massachusetts has reduced funding for its program. Meanwhile, proposals in New York and Connecticut to limit financial help have been dismissed.Beneficiaries enrolled in the drug benefit have coverage until total spending reaches $2,700 and then must pay out-of-pocket for their medications until the total spending reaches $4,350, after coverage. At least 16 states provide financial help to beneficiaries who have reached the coverage gap (AP/Boston Herald, 5/27).
Candela Corporation (NASDAQ: CLZR) announced that two studies have reported superior results on patients who benefited from the Candela Vbeam® laser treatments for bruising resulting from cosmetic procedures. The studies concluded that the Vbeam pulsed-dye laser significantly expedited the healing process, improved outcomes, and provided greater overall patient satisfaction.
A recently released survey on stigma in Rwanda indicates that at least 74% of people in various segments of society who have experienced discrimination are HIV-positive, the New Times/AllAfrica.com reports. The discrimination often is in the form of isolation from family and physical harassment, according to the survey. The study was conducted by the Association of Vulnerable Widows Infected and Affected by HIV and AIDS in conjunction with the Network of People Living with HIV and UNAIDS Rwanda. It found that although 87% of respondents reported never having been denied health services, 88% reported being denied other social services, such as family planning, because of their HIV status. An estimated one-third of respondents reported that their rights had been abused because of their HIV-positive status. Chantal Nyiramanyana, AVVAIS president, said, "We conducted this survey as a way of providing basis for advocacy, policy change, and programmatic interventions by the government and other interested bodies to address stigma and discrimination related to HIV." The survey found that other groups experiencing stigma in the country include commercial sex workers and asylum seekers (Kwizera, New Times/AllAfrica.com, 5/27).
"Nearly 30 years after the discovery of HIV and AIDS, the epidemic is still ravaging black neighborhoods in Baltimore and across the nation," Kevin Fenton -- director of CDC"s National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention -- writes in a Baltimore Sun opinion piece. Fenton writes that "complacency about HIV and the continued stigma associated with the disease are hindering progress by preventing too many African-Americans from seeking either HIV testing and treatment or support from their friends and family," adding that "this is a challenge that can be overcome."According to Fenton, the Obama administration last month "took an important step in confronting the United States" HIV epidemic" when CDC and White House officials announced a five-year campaign called Act Against AIDS, which is "designed to refocus the nation"s attention on the HIV crisis here at home." Fenton notes that 14 black civic organizations -- including the NAACP, the National Urban League, the Southern Christian Leadership Conference and the National Council of Negro Women -- are "joining the CDC to increase knowledge, awareness and action within black communities across the country." He adds that the campaign "will harness the strength and reach of these organizations by enhancing their ability to make HIV prevention a core component of their daily activities." "By raising the visibility of HIV and AIDS, the new campaign also aims to confront and overcome the fear and stigma that help keep HIV alive in black communities," Fenton says. He adds that he has "been encouraged in recent years to see black leaders, including black faith leaders, speak out more openly across the nation about the need to confront HIV and the stigma that persists surrounding this disease." Fenton writes that "[e]nding this epidemic will require not only frank and difficult discussions about HIV but also a shared sense of responsibility and commitment," concluding, "All of us can and must be part of the solution" (Fenton, Baltimore Sun, 5/27).
Telesso Technologies Limited (ASX: TEO), a global healthcare company, has announced the FDA-approved guide wire-assisted peripheral IV catheter it is developing with Vascular Pathways, Inc., has been honored with the Popular Science Invention Award.
Napo Pharmaceuticals, Inc. ("Napo") is proud to announce that the Company is part of the Call to Action led by PATH, UNICEF, and WHO to raise the visibility of diarrheal disease and solutions to address it. The Call to Action includes the invitation to "invest in the research and development of new effective, appropriate and affordable prevention and treatment options for diarrheal disease."
Clinipace, a digital clinical research organization, announced that Inspire Pharmaceuticals, Inc. has selected the company to manage and deploy two phase II studies for the ophthalmic prescription medicine, AzaSite®.
International Stem Cell Corporation (OTCBB:ISCO), the first company to perfect a method of creating human "parthenogenetic" stem cells from unfertilized eggs, has received positive early results from animal trials designed to improve photorefractive keratectomy (PRK), a form of corrective laser eye surgery that offers an improved alternative to LASIK.
A recent report released by Wolters Kluwer Health predicts that by the end of the year, nearly two-thirds of all drug prescriptions will be filled with generic drugs. This march to generics is fueled by several factors, which include the current economy, ever-increasing co-payment requirements for brand name drugs and pharmacies" desire to increase their profits by filling prescriptions with high margin generics versus lower margin brand name medicines.
Cytori (NASDAQ:CYTX) completed enrollment in the first study to investigate adipose derived stem and regenerative cells in chronic heart disease. The trial, which has been named the PRECISE study, was carried out at leading cardiology centers in Europe. It specifically enrolled patients suffering from an advanced form of chronic heart disease, known as chronic myocardial ischemia, for which there is no generally accepted treatment.
RAJ Devices, the regulatory affairs journal published by Informa and covering the medical technology industry, has published a comprehensive feature on how companies in the US can comply with a much stricter code of ethics that medical technology industry association AdvaMed will launch on 1 July.
Drinking cherry juice could help ease the pain for people who run, according to new research from Oregon Health & Science University presented at the American College of Sports Medicine Conference in Seattle, Wash. The study showed people who drank tart cherry juice while training for a long distance run reported significantly less pain after exercise than those who didn"t. Post-exercise pain can often indicate muscle damage or debilitating injuries.
Just as our world buzzes with distractions - from phone calls to e-mails to tweets - the neurons in our brain are bombarded with messages. Research has shown that when we pay attention, some of these neurons begin firing in unison, like a chorus rising above the noise. Now, a study in the May 29 issue of Science reveals the likely brain center that serves as the conductor of this neural chorus.
HRA Pharma, a privately-held,
Oxidative stress has been linked to aging, cancer and other diseases in
A call to action for more research to be undertaken into catheter ablation in the field of ventricular arrhythmia (VA) has been issued in a joint consensus document from the European Heart Rhythm Association (EHRA) a registered branch of the European Society of Cardiology (ESC) and the US Heart Rhythm Society (HRS). The consensus document - launched at Heart Rhythm 2009, the Heart Rhythm Society"s 30th Annual Scientific Sessions, being held 13 to 16 May in Boston - provides an up to date review of indications, techniques and outcomes of catheter ablation for treatment of ventricular arrhythmias, a technique now being offered to increasing numbers of patients.
A new combination therapy of daily consensus interferon (CIFN) and ribavirin is effective for some people with chronic hepatitis C (HCV) who do not respond to standard therapy. The treatment works particularly well in interferon-sensitive patients who have lower fibrosis scores, according to a new study in the June issue of Hepatology, a journal published by John Wiley & Sons on behalf of the American Association for the Study of Liver Diseases (AASLD). The article is also available online at Wiley Interscience.
UK researchers who reviewed pooled clinical trial data covering 95,000 people concluded that there was no net benefit to healthy people taking
Scientists are reporting discovery of a potential new alternative to aspirin, ReoPro, and other anti-platelet agents used widely to prevent blood clots in coronary artery disease, heart attack and stroke. Their study, scheduled for the June 23 issue of ACS Nano, a monthly journal, involves particles of silver - 1/50,000th the diameter of a human hair - that are injected into the bloodstream.
Scientists are reporting a potential solution to a problem that limits the human body"s ability to absorb and use medications for heart disease, Type-2 diabetes, cancer and other conditions. It is a "nano-hybrid microcapsule" that enables the stomach to absorb more of these so-called "poorly-soluble" medicines. Their study is scheduled for the June 1 issue of ACS" Molecular Pharmaceutics, a bi-monthly journal.
CuraGen Corporation (Nasdaq: CRGN) announced plans for three data presentations from its ongoing clinical trials of CR011-vcMMAE, an antibody-drug conjugate that targets GPNMB, in patients with advanced breast cancer and melanoma at the 2009 Annual Meeting of the American Society of Clinical Oncology (ASCO) in Orlando, Florida.
Those in the United States living with HIV/AIDS are more likely to use marijuana than those in Kenya, South Africa or Puerto Rica to alleviate their symptoms, according to a new study published in Clinical Nursing Research, published by SAGE. Those who did use marijuana rate it as effective as prescribed or over the counter (OTC) medicines for the majority of common symptoms, once again raising the issue that therapeutic marijuana use merits further study and consideration among policy makers.
For years, doctors and other health-care providers have managed pregnant patients according to guidelines issued by the American College of Obstetricians and Gynecologists (ACOG). In 1986, ACOG stated, "Regardless of how much women weigh before they become pregnant, gaining between 26-35 pounds during pregnancy can improve the outcome of pregnancy and reduce their chances of having the pregnancy end in fetal death." Until its revised guidelines were released yesterday, the Institute of Medicine (IOM) had recommended that overweight women should gain about 15 pounds during pregnancy.
Continuous Glucose Monitoring (CGM) devices represent a critical step toward achieving automated glucose measurement, offering people with diabetes a promising new tool for maintaining optimal glucose control. A comprehensive review of this rapidly changing field, featuring the most recent research findings and critical analysis, is the focus of a special supplement of Diabetes Technology & Therapeutics, a peer-reviewed journal published by Mary Ann Liebert, Inc. The supplement is available free online at http://www.liebertonline.com/dia
The New York Times, Washington Post and Washington Times recently published opinion pieces on President Obama"s nomination of Judge Sonia Sotomayor to the Supreme Court. Summaries appear below.~ David Brooks, New York Times: "Supreme Court justices, like all of us, are emotional intuitionists" because "they begin their decision-making processes with certain models in their heads," Times columnist Brooks writes, adding that "[t]hese are models of how the world works and should work, which have been idiosyncratically ingrained by genes, culture, education, parents and events," and which "shape the way judges perceive the world." Therefore, the "crucial question in evaluating a potential Supreme Court justice ... is not whether she relies on empathy or emotion, but how she does so," according to Brooks. He writes that Sotomayor "will be a good justice if she can empathize with the many types of people and actions involved in a case, but a bad justice if she can only empathize with one type, one ethnic group or one social class." He concludes, "It"s not whether judges rely on emotion and empathy, it"s how they educate their sentiments within the discipline of manners and morals, tradition and practice" (Brooks, New York Times, 5/29).~ Michael Gerson, Washington Post: By opposing Sotomayor"s confirmation, Republicans could be entering "a trap" by "further alienating Hispanic voters the GOP has recently driven away in droves," which might "confirm an image of Republicans as the party of the male and pale," columnist Gerson writes in a Post opinion piece. He continues, "Barring unforeseen ethical revelations, opposition to Sotomayor seems both politically risky and ultimately futile." However, "Republicans must still enter the trap -- with open eyes and no expectation of gain -- not to defeat a nominee but to maintain a principle" that the court "should be a place where all are judged impartially, as individuals," Gerson writes. He continues that the "Obama/Sotomayor doctrine of empathy challenges this long-established belief," and this "is not a minor matter." According to Gerson, "Concerns about the doctrine of empathy will not defeat Sotomayor -- and perhaps they should not defeat her." However, the "problems raised by selective empathy require a substantive (not harsh or personal) national debate -- and this requires Republicans to carefully, warily, enter Obama"s trap" (Gerson, Washington Post, 5/29).~ Michael Kinsley, Washington Post: "What conservative Republicans don"t like about the Supreme Court can be summarized as three, or maybe four, A"s: abortion, affirmative action and activism," columnist Kinsley writes in a Post opinion piece. He adds that "[r]ecent Republican platforms have pledged to appoint judges who not only will overturn Roe [v. Wade] but will make clear that fetuses have the same rights as people under the 14th Amendment"s guarantee of "equal protection of the laws."" Kinsley continues that supporters of Roe "clearly represent the "activist" side," while opponents of the decision "are right that Roe represents the highest tide of Warren Court activism." However, this "doesn"t mean the critics of Roe are right on the merits;" rather, it means that ""activism" is a near-worthless concept, and comparative activism is nonsense," Kinsley writes. He continues, "Although I am pro-choice, Roe makes me unhappy because it was poorly reasoned, not because it "went further" than other decisions." According to Kinsley, "many opponents of Roe would not be satisfied with merely seeing it overturned and the issue returned to the states," and, in fact, the GOP platform "effectively calls for a litmus test for judges: Will they rule abortion illegal in all 50 states no matter what the people want?" He continues, "Now that would be judicial activism with a vengeance" (Kinsley, Washington Post, 5/29).~ Eugene Robinson, Washington Post: The fact that Sotomayor "is a proud and accomplished Latina" apparently "drives some prominent Republicans into a s
"The Social Security COLA and Medicare Part B Premium: Questions, Answers and Issues," Kaiser Family Foundation Medicare Policy Project: The issue brief examines how Social Security recipients for the first time in 2010 are not expected to receive a cost-of-living adjustment, with no or a low COLA expected through 2012. The brief examines the relationship between the Social Security COLA and the Medicare Part B premium and the effect that such changes have on beneficiaries of both programs (Kaiser Family Foundation release, 5/27).
Family and network oriented, stress-reducing care improves level of overall functioning and mental health in adolescents at risk of developing psychosis, suggests a recent Finnish study.
Members of a USC-led research team say they"ve made a big improvement in a new breed of electronic detectors for viruses and other biological materials - one that may be a valuable addition to the battle against epidemics.
Researchers at the University of Pennsylvania School of Medicine have uncovered variation around two genes that are associated with an increased risk of testicular cancer. Testicular cancer is the most common cancer among young men, and its incidence among non-Hispanic Caucasian men has doubled in the last 40 years -- it now affects seven out of 100,000 white men in the United States each year. The discovery, published in the May 31, 2009 online issue of Nature Genetics, is the first step toward understanding which men are at high risk of disease.
A case report written by Dr Francesco Natale and his colleagues, from the Second University of Naples and Monaldi Hospital, Naples, Italy, reports on the dangers of stimulant chewing gums containing caffeine. The report published in this week÷´s edition of The Lancet describes the story of a teenage boy hospitalized after excessive consumption of this type of product. The authors warn about the high risks of stimulant chewing gums that are widely available to children.
The New York Stem Cell Foundation (NYSCF) announced the award of four new NSYCF-Stanley and Fiona Druckenmiller Fellows. These New York-based post-doctoral scientists join 13 extraordinarily accomplished stem cell researchers from leading research institutions who have been supported by the fellowships program since 2006.
Following calls from the information commissioner for the NHS to improve its data security, after breaches involving the loss of thousands of personal medical records, Bill Gilliam, head of the health sector group at international law firm Eversheds comments:
Interventional radiology is a dynamic and innovative specialty. In the last ten years new image guided therapies for uterine myomata, infertility, pelvic pain, osteoporosis, and varicose veins have largely been developed. Interventional Radiology in Women"s Health, published by Thieme, focuses on women"s health and the expanding role of interventional radiology within this pioneering area of medicine.
Of all cancers, non-small cell lung cancer (NSCLC) represents one of the greatest unmet needs for an effective and life-prolonging treatment. The condition, which accounts for 85 per cent of all lung cancers - roughly 1.4 million worldwide each year - is rarely diagnosed at its earliest and most potentially curable stage when it is amenable to surgical resection. Most patients are diagnosed when the tumour has already advanced to stage III, where it has invaded the chest tissues or mediastinal lymph nodes and is inoperable, or to stage IV where it has spread to other organ sites. Around 30 per cent are diagnosed at stage III and 40 per cent at stage IV. Both stages carry a poor prognosis. From stage III, and following chemo and radiotherapy treatment, median survival has been at best only between 13 and 18 months.
A survey of trauma patients reported in the Medical Journal of Australia has found that compensation-related factors are significant predictors of health care utilisation.
Sequel Systems says the Electronic Prescribe (E-Prescribe) program, in which paper-based health records would be converted to electronic health records (EHRs), would be beneficial to hospital-based and managed services organizations. This not only reduces medical errors made in the reading of written prescriptions - which results in increased liability - but also offers financial incentives by receiving increases in Medicare reimbursements to those organizations that adopt the program.
A new survey published in the British Journal of Cardiology suggests that inconsistencies in clinical guidance for the ongoing management of post-myocardial infarction (MI) patients may contribute to significant variation in clinical practice reported by GPs and practice nurses.1a These findings indicate that, in some areas of the UK, care for post-MI patients after leaving hospital may not be optimal,1b according to authors from the Follow Your Heart group. *
With consumer genetics becoming more of a reality to the average consumer and direct-to-consumer (DTC) genetics tests becoming more available, thought leaders, experts and DTC companies will convene in Boston on June 9-11 for the first annual Consumer Genetics Conference to move the issues to the forefront and demystify this emerging field. Preeminent leaders from government, healthcare, biotechnology and diagnostic fields, will examine consumer genetics, including its practical realities and complex policy considerations; speakers and companies will present new advances and information on available genetic tests and developments in this field. The conference is open to all who are curious, impacted by, and interested in consumer genetics, including consumers (http://www.consumergeneticsconference.com).
Studies overwhelmingly point to regular physical exercise as the crucial medicine for what ails Americans. Physicians have a hard time convincing even healthy patients to take action, but it"s a much harder sell for those with limited movement caused by physical disabilities. They often lack the self-confidence to begin a physical fitness plan, and it"s easy to understand why. They face transportation obstacles to visit an exercise facility. If they can get to the facility, accessing the building and equipment is often difficult or impossible, and fees are often high, says Dr. Zibin Guo, a medical anthropologist in The University of Tennessee at Chattanooga Department of Sociology, Anthropology, and Geography. He says appropriate and interesting exercise is often not available to this group.
On May 13, health care professionals and health care activists gathered on Capitol Hill to demonstrate their support for Senator John Conyer"s HR 676.
A vaccine for one of the most lethal cancers, advanced melanoma, has shown improved response rates and progression-free survival for patients when combined with the immunotherapy drug, Interleukin-2, according to researchers from The University of Texas M. D. Anderson Cancer Center.
The Long Path to Diagnosis
Physicians who treat patients with multiple health problems will fare well under pay-for-performance, which bases physician reimbursement on the quality of care provided, said researchers at Baylor College of Medicine and the Michael E. DeBakey Veterans Affairs Medical Center in Houston in a report in the current issue of the journal Circulation.
The Pima County Health Department is releasing additional
The Institute of Medicine and the National Research Council on Thursday issued revised U.S. weight-gain guidelines for obese pregnant women, in response to rising levels of obesity in the country and growing evidence that weight gain can cause health problems for women and their infants, the New York Times reports. The revision, which is the first since 1990, recommends that obese women -- those with a body mass index of 30 or more -- limit their weight gain to 11 to 20 pounds over nine months. The 1990 pregnancy guidelines did not specifically address weight gain for obese women, telling them instead to follow the recommendations for overweight women. According to health officials, the changes to the recommendations for obese women were required to keep up with the changing weight patterns among women in the U.S. The New York Times reports that about 27% of women of childbearing age are considered obese, while 55% fall into the categories of overweight or obese.The recommendations for women with BMIs of less than 30 did not change. They call for overweight women -- those with a BMI of 25 to 29.9 -- to gain 15 to 25 pounds over nine months, while underweight women -- with BMIs of less than 18.5 -- should gain 28 to 40 pounds, and normal-weight women -- with BMIs of 18.6 to 24.9 -- should gain 25 to 35 pounds (Parker-Pope, New York Times, 5/29).Time reports that pregnant women who do not gain enough weight face a higher risk of stunted fetal growth and preterm delivery. However, it is more common for women to gain too much weight, placing them at higher risk for conditions like gestational diabetes and high blood pressure. In addition, their infants are at increased risk of being born earlier, larger and by cesarean section. Time reports that excessive weight gain can increase a woman"s risk of postpartum obesity and elevate risks of heart disease and stroke because most women do not lose extra pounds gained during pregnancy. Many studies also have suggested that a woman"s gestational weight can predict potential weight problems in her offspring (Kingsbury, Time, 5/28).The committee that developed and issued the revision said that the existing guidelines were essentially on target but that women and their physicians need to work harder to help women reach a normal weight before pregnancy and avoid gaining too much weight during pregnancy, according to the Los Angeles Times (Roan, Los Angeles Times, 5/29). The guidelines also recommend more nutrition and exercise counseling during pregnancy, advising physicians or midwives to consult dieticians to shape a woman"s care regardless of her initial weight, the AP/Yahoo! News reports (Neergaard, AP/Yahoo! News, 5/28). The Los Angeles Times reports that health care professionals are expected to recognize and implement some of the recommendations; however, it is not mandatory to do so.Several experts on maternal obesity and child health expressed disappointment with the guidelines, arguing that obese women should gain little to no weight during pregnancy, according to the Los Angeles Times. They also argue the new guidelines do not do enough to address obesity before pregnancy. Maxine Hayes, state health officer for the Washington State Department of Health, said, "If we wait for every woman to be advised about weight gain after they become pregnant, it"s too late. It puts women and their babies on a trajectory that is unhealthy" (Los Angeles Times, 5/29).
A new study uncovers a gene expression signature that reliably identifies cancer cells whose survival is dependent on a common signaling pathway, even when the cells contain multiple other genetic abnormalities. The research, published by Cell Press in the June 2nd issue of the journal Cancer Cell, identifies critical molecular vulnerabilities, thereby revealing promising therapeutic targets for a common and notoriously treatment resistant cancer.
A study in the June 1 issue of the journal SLEEP found that waist circumference and body mass index (BMI) are consistent, independent risk factors for all severity levels of sleep disordered breathing (SDB) in children, suggesting that as with adult SDB, metabolic factors are important risk factors for childhood SDB.
New research published in the June issue of the British Journal of Psychiatry, shows most mental health settings in England have faced challenges in introducing smoke-free policies.
Plans to replace London"s District General Hospitals with new local hospitals providing fewer services carry clinical risks and need more thought, the BMA says today.
The latest advances in polyp detection, assessment of colorectal cancer risk, and patient sedation during colonoscopy will be presented today at Digestive Disease Week® 2009 (DDW®). Research regarding the size and type of polyps detected during colonoscopy and the risk associated with developing colon cancer offers new insight into the recommended frequency of follow-up preventive colonoscopy. New research also examines the risk of perforation during colonoscopy and new tools allowing physicians to more closely examine polyps during colonoscopy including optical biopsy and deep sedation of the patient will be presented. DDW is the largest international gathering of physicians and researchers in the fields of gastroenterology, hepatology, endoscopy and gastrointestinal surgery.
Even while their blood pressures are still normal, overweight male teens may have elevated levels of a hormone known to increase pressures as well as early signs of heart damage, researchers say.
Treating a common heart rhythm disorder by burning heart tissue with a catheter works dramatically better than drug treatments, a major international study has found.
Testing people for heart disease might be just a finger prick away thanks to a new credit card-sized device created by a team of researchers from Harvard and Northeastern universities in Boston. In a research report published online in The FASEB Journal, they describe how this device can measure and collect a type of cells needed to build vascular tissue, called endothelial progenitor cells, using only 200 microliters of blood. The development is also significant because it allows scientists to collect these cells much more easily than current techniques allow, bringing laboratory-created tissue for vascular bypass surgeries another step closer to reality.
Soccer players and exercise enthusiasts now have another reason to reach for lowfat chocolate milk after a hard workout, suggests a new study from James Madison University presented at the American College of Sports Medicine annual meeting. Post-exercise consumption of lowfat chocolate milk was found to provide equal or possibly superior muscle recovery compared to a high-carbohydrate recovery beverage with the same amount of calories.
ZIOPHARM Oncology, Inc. (Nasdaq: ZIOP) announced today that it presented positive data from both a Phase Ib clinical trial and preclinical dosing studies of orally administered indibulin (ZybulinTM or ZIO-301), the Company"s novel tubulin binding agent, at the 45th Annual American Society of Clinical Oncology (ASCO) meeting held in Orlando, FL, May 29th to June 2nd.
The United Kingdom"s National Institute for Health and Clinical Excellence (NICE) has published a Final Appraisal Determination (FAD) recommending the use of the drug Erbitux® (cetuximab) in combination with chemotherapy as a 1st-line treatment for patients with metastatic (advanced) colorectal cancer (mCRC) who have met specific additional criteria1 - presenting the possibility of potentially curative surgery.2 The treatment is recommended for patients in whom the cancer has spread only to the liver and who have normal or "wild-type" KRAS tumors.1 In the UK, a recommendation by NICE is a prerequisite for funding of a medical treatment by the National Health Service.
"Facing difficult economic times and the uncertainties of national health care reform, some Maryland hospitals are choosing to be swallowed up by larger medical systems, with an unusual string of mergers over the past 16 months and more likely on the way," The Baltimore Sun reports. The consolidations could offer benefits to all those involved. Small hospitals gain "the hope of safe harbor from whatever financial storms are on the horizon, hospital chains "get footholds in new areas, where they can build market share and increase the number of patients they serve," and patients may "gain access to large networks of top-notch doctors, even if the patients live many miles from a major medical institution."
Nancy-Ann DeParle, director of the White House Office of Health Reform, predicted in an interview with Kaiser Health News that a comprehensive health care reform bill would reach President Obama by Thanksgiving, and that she hasn"t given "a moment"s thought" to accepting a scaled-back package.
ZymoGenetics, Inc. (NASDAQ:ZGEN) announced positive final results from a Phase 2 clinical trial in patients receiving 2nd or 3rd line therapy for advanced renal cell carcinoma with the combination of recombinant Interleukin 21 (IL-21) and Nexavar® (sorafenib) tablets. The combination demonstrated considerable clinical benefit, with an overall response rate (as assessed by an independent review) of 21%, a disease control rate of 82%, and progression-free survival (PFS) of 5.7 months in this heavily pretreated population. Results were presented at the American Society of Clinical Oncology meeting.
High-throughput whole-genome analysis is becoming a standard laboratory approach for investigating cellular processes. Next-generation sequencing is replacing microarrays as the technique of choice for genome-scale analysis, because it offers advantages in both sensitivity and scale. The June issue of Cold Spring Harbor Protocols features "Native Chromatin Preparation and Illumina/Solexa Library Construction" from Keji Zhao and colleagues at the National Heart, Lung and Blood Institute. The article describes sample preparation for sequencing of chromatin-immunoprecipitated DNA (ChIP-Seq) to analyze histone modification patterns using native chromatin and the Solexa/Illumina Genome Analyzer. Step-by-step instructions are given for purification of human CD4+ T cells from lymphocytes and chromatin fragmentation using micrococcal nuclease (MNase) digestion, followed by chromatin immunoprecipitation (ChIP) and construction of a library for sequencing. The article is freely available on the website for Cold Spring Harbor Protocols (http://cshprotocols.cshlp.org/cgi/content/full/2009/6/pdb.prot5237).
Implementing measures to improve nutrition, indoor air pollution, immunization coverage and the management of pneumonia cases could be cost-effective and significantly reduce child mortality from pneumonia, according to a study led by the Johns Hopkins Bloomberg School of Public Health. Researchers found that these strategies combined could reduce total child mortality by 17 percent and could reduce pneumonia deaths by more than 90 percent. Pneumonia is a leading cause of death of infants in many developing countries, resulting in 2.2 million deaths each year. The study is published in the June 2009 issue of the Bulletin of the World Health Organization.
Olympus America Inc. has expanded its medical portfolio by introducing the X-Suit NIR®, a biliary metallic stent designed with exceptional anatomic conformability and superior radial support. The X-Suit NIR"s proprietary NIRflex™ cell design provides a physician support and flexibility; both critical to help relieve the symptoms associated with pancreatic, liver and bile duct cancers.
Researchers at Tulane University, in collaboration with Corgenix Medical Corporation, a worldwide developer and marketer of diagnostic test kits, have received a five-year $7,073,538 grant from the National Institutes of Health (NIH) for continued development of detection kits for Lassa viral hemorrhagic fever, a serious disease spread by contact with infected rodents. Viral hemorrhagic fevers are characterized by fever and bleeding disorders and can progress to high fever and shock. Lassa fever is estimated to infect 300,000 to 500,000 people per year across West Africa, resulting in approximately 5,000 deaths.
Pakistan has obtained international support for its efforts to fight tuberculosis and lower infant and maternal mortality rates, Mir Aijaz Hussain Jakhrani, the health minister, said recently after returning from the 62nd World Health Assembly (WHA), the International News reports.
PTI/The Hindu examines a recently launched national HIV prevention program that will target an estimated 5 million truck drivers in India, a group health experts consider to be at high-risk for HIV.
Plexxikon Inc. today announced preliminary data from a Phase 1 clinical study investigating PLX4032 (R7204). PLX4032 is a novel, oral and highly selective drug that targets the BRAFV600E cancer-causing mutation that occurs in most melanomas and about eight percent of all solid tumors. In patients whose cancer harbors this mutation and who were treated with therapeutic doses of PLX4032, tumor shrinkage and extended progression-free survival have been observed. Currently, two extension studies are being conducted in mutation-positive melanoma and colorectal cancer patients. Following the initial positive findings announced today, larger clinical trials to support a registration program for product approval are targeted to start later in 2009. Plexxikon and Roche are co-developing PLX4032 under their 2006 license and collaboration agreement.
Black religious leaders across the country are urging the passage of a bill (H.R. 1964) that would provide more than $600 million in funding for faith-based prevention, testing and outreach programs, the St. Petersburg Times reports. The bill, named the National Black Clergy for the Elimination of HIV/AIDS Act of 2009, calls for programs targeting specific populations within the black community, including young people, substance users and inmates, among others. The bill, introduced in Congress this spring, has been referred to the House Committee on Energy and Commerce (Zayas, St. Petersburg Times, 6/1).
Health care costs soared nearly 50 percent between 2000 and 2006, adding an urgency for reform that may help Democrats pass a major overhaul before the year-end deadline set by the White House, Bloomberg reports. "You come to a point where you can"t afford health care as it is and you have to reform it," Rep. John Dingell, D-Mich., told Bloomberg. As Congress seeks to capitalize on spending growth, industry groups have arrived at the table with their own suggestions for cutting up to $1.7 trillion in spending over the upcoming decade (Litvan, 6/2).
B. Braun Medical Inc. (B. Braun), a leader in infusion therapy and pain management, said today it anticipates U.S. Food and Drug Administration (FDA) approval for 2g Cefazolin for Injection USP and Dextrose Injection USP in B. Braun"s DUPLEX(R) Drug Delivery System.
CQ HealthBeat reports on reactions to Cindy Mann"s appointment as Director of the Center for Medicaid and State Operations, noting that liberals are hailing her appointment and "saying she"ll counter steps taken by the Bush administration to tighten eligibility and alter benefits."
A troubled county jail, where hundreds of lawsuits have stemmed from mistakes in managing the inmates" health information, would be a perfect testing ground for electronic medical records, the Arizona Republic reports. But Maricopa County officials have not acted on repeated recommendations to implement such a system, "even when faced with hundreds of lawsuits and the loss of accreditation for CHS operations."
The American Society for Radiation Oncology (ASTRO) has recently updated its award-winning patient booklet, Radiation Therapy for Cancer that provides information for people living with cancer and their loved ones who are exploring radiation therapy as a treatment option.
Bayer Schering
A blood-pressure medicine has been shown to reverse the effects of early-stage liver failure in some patients.
The World Milk Day provides an opportunity to focus attention on milk and to publicise activities connected with milk and the milk industry. The fact that many countries choose to do this on the same day lends additional importance to individual national celebrations and shows that milk is a global food.
Opponents and supporters of abortion rights on Monday said they expect the murder of Kansas abortion provider George Tiller on Sunday to further intensify the debate over reproductive rights in the U.S., with some abortion-rights advocates expressing concern that the killing could spur a new wave of protests or violence from opponents, the Washington Post reports. Tiller, one of the few U.S. doctors who performed abortions later in pregnancy, was shot to death on Sunday at his church in Kansas. According to the Post, Tiller"s death has brought the issue of violence back into the spotlight in the abortion debate at a time when President Obama is urging both sides to find "common ground." Nancy Keenan, president of NARAL Pro-Choice America, said the "ongoing pattern of hateful rhetoric" used by some in the antiabortion-rights movement contributes to violence like Tiller"s shooting (Slevin, Washington Post, 6/2). Keenan singled out groups that she said have used "hateful rhetoric" in recent months. "If they truly abhor the violence their rhetoric is encouraging, then they need to stop using the inflammatory phrases to describe the people they don"t agree with," she said, adding that "until then, I think their claims of the shock of Dr. Tiller"s murder ring very hollow." The antiabortion-rights group Operation Rescue is at the center of debate over whether certain rhetoric stokes violence in the movement, NPR"s "Morning Edition" reports. The group"s founder, Randall Terry, said after the shooting, "What that man did by shooting George Tiller is wrong. Period" (Rovner, "Morning Edition," NPR, 6/2). However, Terry also called Tiller a "mass murderer" who "reaped what he sowed" (Milligan, Boston Globe, 6/2). Tom McClusky, vice president of the Family Research Council"s legislative arm, said the group is concerned with "how an action like this might be exploited" by abortion-rights supporters, particularly the idea of condemning the entire antiabortion-rights movement for Tiller"s death. He said that FRC is "already seeing some indications of people trying to throw everybody into the same boat" ("Morning Edition," NPR, 6/2).The Rev. Rob Schenck, president of the National Clergy Council, said that Terry"s views do not represent the modern antiabortion-rights movement. Schenck added that he believes "that a lot of pro-life leaders from the past are not carefully, prayerfully thinking through the moral consequences of an act like" the shooting. Schenck and abortion-rights opponents also expressed concerns that the murder will harm the credibility of their attempt to block the Supreme Court nomination of Judge Sonia Sotomayor. "When an act like this happens, it becomes a greater threat to the pro-life movement than anything the pro-choice movement" could do, Schenck said (Boston Globe, 6/2). Andy Wollen of the centrist group Kansas Traditionalist Republican Majority said that Tiller"s shooting "brings home the impact of the kind of rhetoric that the hard right uses when they talk about abortion." He said that when antiabortion-rights advocates "called him "Tiller the Killer" and they call their political opponents "baby killers," as they do on a regular basis, they"re opening the doors" to acts of violence.Meanwhile, USA Today reports that U.S Attorney General Eric Holder has increased security measures for abortion providers and clinics across the country, including Tiller"s clinic (Bello/Stone, USA Today, 6/2). Dan Monnat, Tiller"s attorney, said that the clinic is currently closed for mourning but will reopen next week to serve women who "came to Dr. Tiller because they had nowhere else to turn" (Washington Post, 6/2). Scott Roeder, the man accused of shooting Tiller, remained in custody in Wichita, Kan., the day after the shooting. USA Today reports that the district attorney has until today to file charges (USA Today, 6/1).
The same techniques used to detect suspicious activity in airports, stadiums and other public places are now being used by the UCF researcher who invented them to find and measure potentially life-threatening brain tumors.
Older people in Britain are being drugged and robbed when they need care.
Dr. Dev GnanaDev, president of the California Medical Association, issued the following statement after Gov. Arnold Schwarzenegger called on the state Legislature to swiftly enact his proposed budget cuts.
The
Data from the Phase III ZODIAC1 study in advanced non-small cell lung cancer patients, with the investigational drug vandetanib, were presented today at the American Society of Clinical Oncology (ASCO) meeting in Orlando. Results show that the study met its primary endpoint, demonstrating that the addition of vandetanib to docetaxel resulted in a statistically significant improvement in progression-free survival (PFS), the length of time a patient lives without their cancer growing (hazard ratio [HR] 0.79, 97.58% CI 0.70-0.90; PAbout vandetanib
As policymakers consider ways to cut health costs as a part of health reform, a new national survey of physician practices finds that physicians on average are spending the equivalent of three work weeks annually on administrative tasks required by health plans. According to the study by Lawrence P. Casalino, M.D., Ph.D., of Weill Cornell Medical College and colleagues, physician practices report that overall the costs of interacting with insurance plans is $31 billion annually and 6.9 percent of all U.S. expenditures for physician and clinical services. The study, published in the online issue of Health Affairs, was co-funded by The Commonwealth Fund and the Robert Wood Johnson Foundation"s Changes in Health Care Financing and Organization (HCFO) Initiative.
Collaboration research carried out by the teams of Jordi Surrallés, Universitat Autònoma de Barcelona (UAB); Juan Carlos IzpisÃôa-Belmonte and Angel Raya, Centre for Regenerative Medicine of Barcelona (CMRB); and Juan Antonio Bueren, Centre for Energetic, Environmental and Technological Research (CIEMAT), has resulted in the generation of blood cells from skin cells of patients with a genetic disease known as Fanconi anemia. The process is based on gene therapy and cell reprogramming techniques in which cells similar to embryonic stem cells known as induced pluripotent stem (iPS) cells can be generated. The research article was published in this week"s digital version of Nature.
A closer look at regulatory and clinical concerns with generic immunosuppression medications in thoracic transplantation is required, according to an educational advisory by the International Society for Heart and Lung Transplantation (ISHLT) in the July 2009 issue of The Journal of Heart and Lung Transplantation, published by Elsevier.
Working with a population of individuals at risk for gastrointestinal cancers, researchers at Fox Chase Cancer Center have learned that many people misjudge their actual degree of cancer risk and, therefore, their true need for prevention support. Strategies for accurately assessing cancer risk are critical for appropriately targeting educational, counseling, and diagnostic res to prevent cancer in as many individuals as possible, the investigators say.
The scientific and medical publisher, BMJ Group, is to publish additional themed editions of the British Journal of Sports Medicine (BJSM), supported by the International Olympic Committee (IOC), it was announced today.
ASD Centers, LLC has expanded the clinical study started in the Dallas, Texas area to include other locations. This study is designed to examine mitochondrial dysfunction and how L-carnitine supplementation affects behavior, cognition, muscle strength, and health/physical traits in those with a diagnosed autism spectrum disorder (ASD).
Researchers affiliated with Natura Therapeutics, Inc., Tampa, Florida, and the University of South Florida (USF) have jointly received a one-year, $110,000 Small Business Innovation Research (SBIR) grant from the National Institutes of Health"s (NIH) National Center for Complementary and Alternative Medicine to continue studying TeaMem™, a compound made from green tea.
Results from a number of clinical trials were presented during the Digestive Disease Week (DDW) in Chicago this week, revealing new outcomes data related to endoscopic radiofrequency ablation using the HALO ablation system for eradicating a pre-cancerous esophageal condition known as Barrett"s esophagus. Among them, reports included durability outcomes from a randomized sham-controlled trial, safety and efficacy outcomes from a large U.S. registry of 429 patients, a randomized trial comparing ablation to endoscopic resection, and the largest European series to date in patients with high-grade dysplasia and early cancer.
The United Nations World Food Programme (WFP) announced
Several newspapers on Wednesday published editorials and opinion pieces responding to the shooting death of Kansas abortion provider George Tiller, who was one of the few physicians in the country providing care for women in need of the procedure later in pregnancy. Summaries appear below.Editorials~ Boston Globe: Although officials are calling Tiller"s murder ""the act of an isolated individual," ... the generalized culture of violence and hate in the antiabortion movement that feeds the fanaticism of disturbed individuals with guns is not so easily explained away," a Globe editorial states. The editorial notes, "Many responsible abortion opponents, including Americans United for Life, condemn the killing," but "other so-called pro-life leaders insist on finding a moral equivalence between Tiller"s murder and abortion." The editorial continues, "Also victimized by Tiller"s murder are the anguished women who have sought late-term abortions because their pregnancies have gone horribly wrong." According to the editorial, the "sad irony" is that these procedures "are not a matter of "choice,"" as the "overwhelming majority of these women desperately wanted their children to be born." It adds, "Tiller"s brave and compassionate care saved the lives of these women and their futures as mothers." In his speech last month at the University of Notre Dame"s commencement ceremony, President Obama "called for people of good will on both sides of the abortion issue to bridge the divide," the editorial states, concluding, "An end to the hateful rhetoric over issues of faith that lead unhinged individuals to murder would be a good place to start" (Boston Globe, 6/2).~ USA Today: Tiller"s "insistence" on continuing to practice, despite protests and threats of violence, "was remarkably courageous," but, "[r]egrettably, threats by antiabortion activists have worked all too well," a USA Today editorial states. According to the Guttmacher Institute, the number of abortion providers has decreased by 40% since a peak in 1982, and 87% of U.S. counties have no provider, forcing many women to travel long distances to obtain care, the editorial says. "Mainstream pro-life groups should not be blamed for the actions of a suspected killer who appears to have lurked in the violent and twisted fringe of the movement," the editorial continues. However, the "braying of cable TV hosts," such as Fox News" Bill O"Reilly, "and activists such as Operation Rescue founder Randall Terry contributes to a climate of intolerance that can encourage deranged individuals," the editorial says. According to USA Today, "Thwarted in legislatures and courts, some antiabortion activists are achieving with intimidation and harassment what they can"t through the political process," but "[r]egardless of personal beliefs about abortion, authorities have an obligation to protect those providing and receiving abortion services, and to prosecute those who harass or threaten them." The editorial concludes that "Tiller"s death will only be compounded if it frightens away more doctors and makes a legal procedure even harder to come by" (USA Today, 6/3).~ Washington Post: Tiller"s death "is a tragedy for his family, his patients and his profession," and "[i]t should serve as a wake-up call that more must be done to ensure that women have access to this legal procedure," a Post editorial states. "It is unclear how this violence has affected decisions by health care providers," according to the editorial. However, it is clear that "the number of places where women can go for abortions has been declining since 1982," and "[v]ery few are performed in hospitals -- a sign that mainline medicine is not living up to its responsibility," the editorial says. The editorial notes that Attorney General Eric Holder "is offering U.S. Marshals Service protection for abortion clinics and the doctors who staff them," concluding, "It"s the right call, but one that underscores the urgency of coming up with better solutions for the delive
Esomeprazole significantly reduced the occurrence of gastric and duodenal ulcers and upper gastrointestinal (GI) symptoms in patients taking low-dose aspirin for risk reduction of adverse cardiovascular (CV) events[i], such as myocardial infarction (MI) and ischaemic stroke, according to new data presented today at the Digestive Diseases Week annual meeting (DDW, 30thMay - 4th June, Chicago).
The Centers for Medicare & Medicaid Services is preparing to revive competitive bidding program for durable medical equipment that industry members helped sink last summer when it was originally scheduled to take effect, CQ HealthBeat reports. The agency had anticipated a 26 percent savings for wheelchairs, oxygen tanks and other pieces of equipment through the program. But a lobbying group for the suppliers, the American Association for Homecare, successfully urged Congress to shut down the program before it went into effect.
"Advocates for the elderly in California say recent budget cuts are dramatically affecting the ability of social service programs to keep up with demand" at a time when "the state"s elderly population - and the incidents of elder abuse - are exploding," NPR reports. One example is Contra Costa County, where the Aging and Adult Services Program laid off two-thirds of the staff who "investigate abuse complaints of elderly and dependent adults." The county is now "turning over virtually all of its self-neglect cases to some other agency - often, the police." The Contra Costa situation is "so severe that the county grand jury recently concluded that Adult Protective Services no longer has the res to carry out its legal mandate to investigate physical and financial abuse complaints." This comes at a time when complaints of elder abuse are on the rise. According to "national studies," only "1 in 5 elder abuse cases is reported" (Siler, 6/3).
Genes trump environment as the primary reason that some adolescents are more likely than others to be victimized by crime, according to groundbreaking research led by distinguished criminologist Kevin M. Beaver of The Florida State University.
Navajo County Public Health Services District officials announced today the first case of 2009 H1N1 in Navajo County. The Arizona Department of Health Services Lab confirmed that an 18 year old patient at Little Colorado Medical Center tested positive for the illness. The patient has subsequently been treated and released.
Because bleeding from the reproductive tract is a naturally occurring event during menstruation and childbirth, women who exhibit menorrhagia, or excessive bleeding after their menstrual cycle, may have underlying diseases that are underdiagnosed. In order to address important issues related to the diagnosis and management of reproductive tract bleeding in women with bleeding disorders, a consensus conference was convened. Results are published in the July 2009 issue of the American Journal of Obstetrics & Gynecology.
The new H1N1 swine flu virus claimed the life of a 20-year old Chicago woman on Saturday, one day after giving birth to a baby via Cesarean
Stem cells play a role in heart muscle rejuvenation by attracting cells from the body that develop into heart muscle cells. They have been successfully used to halt or reverse cardiac injury following heart attack, but not to prevent injury before it occurs.
Data was announced today that demonstrated Salix Pharmaceuticals" (NASDAQ:SLXP) APRISO™ (mesalamine) 0.375g extended-release capsules had a favorable safety profile in patients in remission from ulcerative colitis (UC) for up to 24 months. APRISO is approved for use up to six months. The majority of treatment-emergent adverse events were mild or moderate in intensity, and were similar to what was seen during the 6-month phase 3 trials. The study, which is the first to examine the long-term safety profile of APRISO, was presented at the Digestive Disease Week (DDW) annual meeting in Chicago, Illinois.
While the number of new cases of HIV in Wisconsin has stabilized over the last decade, women now represent more of the overall number of cases, the AP/Chicago Tribune reports (AP/Chicago Tribune, 6/2). According to Mike Gifford, CEO of the AIDS Re Center of Wisconsin (ARCW), 21 percent of new infections are women, compared with 16 percent in the 1990s and 6 percent in the1980s. Gifford says that women need to be better informed about their risk of contracting HIV. Christina Colon, ARCW"s associate director of prevention, said the organization is targeting women"s health fairs to raise awareness (Simonson, Wisconsin Public Radio, 6/1).
Sleeping tablets have been associated with a four-fold increase in suicide risk in the elderly. Researchers writing in the open access journal BMC Geriatrics have shown that, even after adjusting for the presence of psychiatric conditions, sedatives and hypnotics were both associated with an increased risk of suicide.
In an ambitious effort to further Yale University"s engagement in global health, President Richard C. Levin announced today the launch of the Yale Global Health Initiative. This is the first endeavor of the University"s new Jackson Institute of Global Affairs, which was announced in April. The purpose of the new initiative is to unite the many global health efforts across campus, foster innovative educational programs to address the growing student interest in global health, and stimulate and support faculty research to enhance healthcare around the world.
Medical problems contributed to nearly two-thirds (62.1 percent) of all bankruptcies in 2007, according to a study in the August issue of the American Journal of Medicine that will be published online Thursday. The data were collected prior to the current economic downturn and hence likely understate the current burden of financial suffering. Between 2001 and 2007, the proportion of all bankruptcies attributable to medical problems rose by 49.6 percent. The authors" previous 2001 findings have been widely cited by policy leaders, including President Obama.
Results from a Phase III study presented at the American Society for Clinical Oncology (ASCO) Annual Meeting in Orlando, Florida today show that patients with advanced non-small cell lung cancer (NSCLC) who received erlotinib (Tarceva®) as first-line maintenance treatment benefited from a significant (29%) improvement in the time they lived without the disease advancing, compared with those who received placebo1. Patients in the global multicentre SATURN trial, which included patients from the UK, received maintenance treatment with erlotinib if their cancer had not progressed on initial chemotherapy. The data showed a significant improvement in the length of time patients lived without their disease getting worse, and without the need for further chemotherapy. 1 The improvement was seen in both of the main types of NSCLC (squamous cell as well as non-squamous cell) and these results form the basis of a submission for regulatory approval of erlotinib to be used in the first-line maintenance setting. 1 Erlotinib is not currently licensed for first line maintenance treatment in NSCLC lung cancer in the UK.
The demand for more user-friendly healthcare IT professional services has been increasing across Europe. Companies that have delivered the right blend of 360 degree consulting, easier and shorter training sessions and exceptional operational services along with round-the-clock support and maintenance services have been displaying market leadership in terms of revenues and number of installed bases.
The most reliable method of diagnosing gout is to aspirate the joint in order to obtain fluid
The United Nations World Food Programme (WFP) announced
In this study data from three studies comparing the new oral anticoagulant rivaroxaban against enoxaparin injected subcutaneously was assessed and conclusions drawn about effectiveness of both types of treatment.
A study published provides results which challenge the current NICE guidelines (set in April 2007) relating to the use of low-molecular weight heparin (LMWH) rather than aspirin as a thromboprophylaxis following orthopaedic surgery.
Hip resurfacing can be a good alternative to total hip replacement (THR) in young adults because it conserves bone and it has acceptable short- to medium-term results. However, there have been concerns about fractures of the femoral neck with this procedure, partly due to notching and varus alignment during implantation.
In the quest for new approaches to treating and preventing disease, one appealing route involves turning genes on or off at will, directly intervening in ailments such as cancer and diabetes, which result when genes fail to turn on and off as they should.
Scientists at the Institute for Research in Immunology and Cancer (IRIC) of the Universitç© de Montrç©al have discovered a key mechanism used by cells to efficiently distribute chromosomes to new cells during cell multiplication. Published in the journal Molecular Cell, the study is the first to demonstrate that this mechanism relies on the polo kinase, an enzyme implicated in several cancers. Inhibiting this mechanism could be key to developing effective therapies to treat cancer.
Many hospitalized patients overestimate their chance of surviving an in-hospital cardiac arrest and do not know what CPR really involves, a University of Iowa study has shown.
Informing men that a new vaccine to prevent human papillomavirus (HPV) would also help protect their female partners against developing cervical cancer from the sexually transmitted infection did not increase their interest in getting the vaccine, according to a new Florida State University study.
Infants born extremely preterm are surviving at a high rate, with about 70 percent of infants born alive between 22 and 26 weeks of gestation in Sweden surviving at least one year, with high rates of interventions being used to improve survival, according to a study in the June 3 issue of JAMA, a theme issue on child and adolescent health.
Danish children who move frequently appear to have an increased risk of attempted or completed suicide between ages 11 and 17, according to a report in the June issue of Archives of General Psychiatry, one of the JAMA/Archives journals.
In the face of rising health care costs, a new study has found that older adults were less likely to identify the plan that minimized their total annual cost and were likely to mistakenly think they had chosen the lowest-cost plan. The study, funded by the Robert Wood Johnson Foundation® Investigator Awards in Health Policy Research, is currently available online, and will be published in the August 2009 issue of Health Services Research.
ACCESS PHARMACEUTICALS, INC. (OTC Bulletin Board: ACCP), announced that new Thiarabine preclinical efficacy data will shortly be published demonstrating that thiarabine combined with clofarabine provides much greater antitumor activity than achieved by either agent alone. In one colorectal cancer model, 66% of mice were cured of their tumors. The publication which will appear in the journal "Cancer Chemotherapy and Pharmacology," was based on work conducted by Access" collaborators at the Southern Research Institute. The paper is entitled "Enhancement of the in vivo antitumor activity of clofarabine by 1-beta-D-[4-thio-arabinofuranosyl]-cytosine" (thiarabine).
As the administration searches for ways to pay for health care reform and restrain medical costs, President Obama suggested Wednesday that he would consider transferring the power to set Medicare reimbursement rates from Congress to the independent advisory agency known as MedPAC, MedPage Today reports. The move reflects legislation introduced by Sen. Jay Rockefeller, D-W.Va., last month that would move MedPAC into the executive branch as "a regulatory board similar to the Federal Reserve ... The move would transfer the power to set reimbursement rates from Congress -- and perhaps the interest groups that lobby it -- to an agency that critics say is better equipped to make nuanced medical payment decisions" (Walker 3/09).