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Washington D.C., Makes Improvements On HIV/AIDS Efforts, But More Work To Be Done, Report Finds; District Expands STD Testing Program For Students
The fifth annual report card from the Washington, D.C.,-based Appleseed Center for Law and Justice examining the district"s response to HIV gives the city "high marks for rapid testing, interagency coordination, surveillance and fighting the disease in the D.C. Jail," but finds that the city falls short in other areas, the Washington Examiner reports (Neibauer, 8/5). "The government also received above-average grades for leadership, managing grants to groups that help people with the illness, and monitoring the effectiveness of those programs," the Washington Post reports. However, "While Mayor Fenty and his administration deserve recognition for the continued support of ò€¦ numerous [HIV/AIDS Administration] initiatives, his public appearances and statements about the epidemic have fallen short of his enthusiasm for action inside the government," the report said. The report added that the district could do more to address HIV and recommended that HAA assess whether the improvements they have made are reducing the spread of the virus, according to the Post (Fears, 8/5).
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Caucasians Are At Higher Risk Of Developing Ewing's Sarcoma Than Other Races
The largest analysis of its kind has found that Caucasians are much more likely than people in other racial/ethnic groups to develop a rare bone and soft tissue cancer called Ewing"s sarcoma. In addition, among Caucasians with this cancer, men are more likely to die than women. Published in the August 1, 2009 issue of CANCER, a peer-reviewed journal of the American Cancer Society, the study indicates that examining the gender and racial differences related to Ewing"s sarcoma could provide a better understanding of the disease and could lead to improved treatments for patients.
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Children With Sickle Cell Disease Need A Good Night's Sleep
Children with sickle cell disease tend to have interrupted sleep many times during the night leaving them tired and irritable during the day.
Diagnostics

News From The Journal Of Clinical Investigation, July 20, 2009

commentary, Geneviève de Saint Basile and Gaël Ménasché, at INSERM U768, France, highlight the importance of this work and suggest future studies to define more precisely the molecular stage of lytic granule formation controlled by EBAG9. TITLE: The tumor-associated antigen EBAG9 negatively regulates the cytolytic capacity of mouse CD8+ T cells https://www.the-jci.org/article.php?id=37760 AUTHOR CONTACT: Armin Rehm Max-DelbrÃøck-Center for Molecular Medicine, Berlin, Germany. Uta E. Höpken Max-DelbrÃøck-Center for Molecular Medicine, Berlin, Germany. ACCOMPANYING COMMENTARY TITLE: EBAG9 tempers lymphocyte killing activity https://www.the-jci.org/article.php?id=40270 AUTHOR CONTACT: Geneviève de Saint Basile INSERM U768, Paris, France. HEPATOLOGY: Balancing liver regeneration and injury In some clinical situations, surgical removal of a massive proportion of the liver or transplantation with a partial liver graft (something known as small-for-size transplantation) is the only option. In both contexts, liver regeneration is crucial to the success of the procedure. One factor linked to impaired liver regeneration is the extent of ischemia-reperfusion injury (IRI), an unavoidable consequence of surgery that occurs when blood reenters the tissues after a period of oxygen deprivation (ischemia). Previous studies have implicated the complement system, a group of blood proteins activated sequentially in inflammatory situations, in both IRI and liver regeneration. In a new study, Stephen Tomlinson and colleagues, at the Medical University of South Carolina, Charleston, have revealed the existence of a balance between complement-dependent injury and regeneration in a combined mouse model of IRI and removal of large portions of the liver. In particular, there was a threshold of complement activation above which it promoted liver regeneration, and this involved the proteins ASP and C5L2. The authors therefore suggest that therapeutic modulation of the complement system might help prevent liver regeneration failure in patients who have had large proportions of their liver removed or undergone small-for-size transplantation. TITLE: A complement-dependent balance between hepatic ischemia/reperfusion injury and liver regeneration in mice https://www.the-jci.org/article.php?id=38289 AUTHOR CONTACT: Stephen Tomlinson Medical University of South Carolina, Charleston, South Carolina, USA. Karen Honey Journal of Clinical Investigation

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