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MicroRNAs Help Control HIV Life Cycle
Scientists at Burnham Institute for Medical Research (Burnham) have discovered that specific microRNAs (non-coding RNAs that interfere with gene expression) reduce HIV replication and infectivity in human T-cells. In particular, miR29 plays a key role in controlling the HIV life cycle. The study suggests that HIV may have co-opted this cellular defense mechanism to help the virus hide from the immune system and antiviral drugs. The research was published today in the journal Molecular Cell.
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Administration's Paygo Plan Will Overlook Health Reform, Other Health Spending
President Obama urged Congress to enact into law tough financial rules requiring them to offset any new spending or taxes, but was clear that where health care is concerned, lawmakers should overlook those rules, Bloomberg reports. "Under fire from Republicans for his spending proposals, Obama is seeking to impose a "pay-as-you-go" system on the budget to demonstrate his commitment to fiscal restraint" (Faler and Runningen, 6/9).
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Revealing Leukemia-Initiating Cells
Two new studies reveal a way to increase the body"s appetite for gobbling up the cancer stem cells responsible for acute myeloid leukemia (AML), a form of cancer with a particularly poor survival rate. The key is targeting a protein on the surface of those cells that sends a "don"t eat me" signal to the macrophage immune cells that serve as a first line of defense, according to the reports in the July 24th issue of the journal Cell, a Cell Press publication.
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WHO Network Supports Efforts To Address Noncommunicable Diseases In Development Goals

Noncommunicable diseases such as heart attacks, strokes, cancers, diabetes, respiratory diseases, and common injuries account for the vast majority of all global deaths, but because they are not yet included as priorities in the global development agenda, donors and international organizations have yet to pledge support to help developing countries address these leading health problems. As the UN Economic and Social Council (ECOSOC) meets in Geneva this week to focus on global public health commitments, many health and development leaders will call upon the international development community to integrate indicators on noncommunicable diseases and injuries into the core Millennium Development Goals (MDGs) monitoring and evaluation system. To support these efforts, the World Health Organization (WHO) today announced the launch of a network of leading organizations and experts from around the world. The network will scale up action to combat noncommunicable diseases, strengthen global partnerships and help governments plan and implement measures to reduce the burden of these diseases. The new Global Noncommunicable Disease Network (NCDnet) will unite currently fragmented efforts by bringing the cancer, cardiovascular, diabetes and respiratory communities together with tobacco control, healthy diets, and physical activity advocates. Integrating the prevention of noncommunicable diseases and injuries into the national and global development agendas is not only achievable but also a priority for developing countries," said Dr. Ala Alwan, Assistant Director-General Noncommunicable Diseases and Mental Health, WHO. "The goals of the new network are to increase focus on the prevention and control of noncommunicable diseases, to increase re availability and to catalyse effective multi-stakeholder action at global and country levels." Strengthened by the support of the World Bank, the World Economic Forum, and leading NGOs such as the World Heart Federation, the International Diabetes Federation and the International Union against Cancer, NCDnet will advocate for action to raise the priority accorded to noncommunicable diseases in development work at global and national levels. "Noncommunicable diseases are a serious threat to global well-being," said Richard Samans, Managing Director of the World Economic Forum. "They present a growing economic and social challenge for many developed and developing countries. At the World Economic Forum we are committed to working with WHO, and in collaboration with other international partners, to build an effective Global Noncommunicable Disease Network." "The challenges policy makers face include how to address the links between noncommunicable diseases and poverty, how to minimize the health and economic losses among the economically active population, and how to prepare for the pressures on health systems resulting from the growing numbers of people with noncommunicable diseases," commented Joy Phumaphi Vice-President of the Human Development Network of the World Bank. "I want to highlight the glaring omission of noncommunicable diseases in the Millennium Development Goals. I believe that this is a serious omission and this anomaly should be corrected. It is in this light that I propose we seriously consider an MDG-plus which would set goals for noncommunicable diseases, as we have done for other public health challenges," commented Minister of Health Dr Leslie Ramsammy of Guyana. Noncommunicable diseases cause 38 million deaths annually and together with injuries are responsible for 70% of all global deaths, with 80% of these deaths occurring in low- and middle-income countries. WHO estimates that globally, deaths from noncommunicable diseases are forecast to increase by 17% over the next 10 years, with the greatest increase projected in the African Region (27%) followed by the Eastern Mediterranean Region (25%). WHO


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