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ZymoGenetics Reports Encouraging Phase 2 Results In Renal Cell Cancer For IL-21 With Nexavar(R)
ZymoGenetics, Inc. (NASDAQ:ZGEN) announced positive final results from a Phase 2 clinical trial in patients receiving 2nd or 3rd line therapy for advanced renal cell carcinoma with the combination of recombinant Interleukin 21 (IL-21) and Nexavar® (sorafenib) tablets. The combination demonstrated considerable clinical benefit, with an overall response rate (as assessed by an independent review) of 21%, a disease control rate of 82%, and progression-free survival (PFS) of 5.7 months in this heavily pretreated population. Results were presented at the American Society of Clinical Oncology meeting.
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The Ozone Man Treats Xaverian High School To Prevent Spread Of Contaminated Swine Flu Within Its Indoor Environments
The Ozone Man, Inc. (OTCBB: OZOM), dba TOMI Environmental Solutions, or TOMIES, announced today the completion of a deep cleaning treatment of Xaverian High School with a student body of 1400 located in Brooklyn, New York. The Ozone Man"s treatment eliminated contaminants including Swine Flu "H1N1" along with inactivating viruses. The Ozone Man"s treatment also eliminates odor, mold spores and kills bacteria in the treated areas. Its proprietary Ultraviolet Ozone Generators produce the cleanest ozone south of the stratosphere, helping to ensure the health, safety and well being of the building and its inhabitants.
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Washington Times Opinion Piece, Editorial Discuss DOJ Nominee Johnsen
The Washington Times recently published an opinion piece and an editorial discussing President Obama"s nomination of Indiana University law professor Dawn Johnsen to head the Office of Legal Counsel in the Justice Department. Summaries appear below. ~ Mickey Edwards/William Sessions, Washington Times: The Senate should "act expeditiously to approve" Johnsen"s nomination because "her views on the limits of presidential power are precisely what the Constitution envisions and conservatives have long championed," Edwards, vice president of the Aspen Institute and author of "Reclaiming Conservatism," and Sessions, a partner at the law firm Holland & Knight, write in a Times opinion piece. According to the authors, Johnsen "made her views clear" on the limits of presidential power when she joined a bipartisan group of lawyers that declared that the Office of Legal Counsel should promote "presidential adherence to the rule of law." Edwards and Sessions write that Johnsen is being criticized for "being blunt, unserious and critical of presidential policies." However, these attacks are unwarranted, they write, noting that in the legal profession, "a little blunt talk to a client -- in this case, the president of the United States -- might be required." Edwards and Sessions continue, "What is needed in the Office of Legal Counsel is a person with the constitutional understanding to know that even presidents with whose politics she agrees must obey both the Constitution and federal statutes and who has the gumption to say so, even if the advice won"t be well received" (Edwards/Sessions, Washington Times, 5/21).~ Washington Times: The editorial states that Johnsen "is so radical" that 31 Republican Indiana state senators on Monday sent a letter to Sens. Evan Bayh (D-Ind.) and Dick Lugar (R-Ind.) asking them to oppose her confirmation. The Republican senators called Johnsen"s views supporting abortion rights "extremely radical" and said she often uses "harsh, sensationalizing rhetoric" in her writings on Supreme Court cases, the editorial states. According to the editorial, Johnsen"s "political advocacy shows a profound disregard for the courts" proper role" because she considers the courts "as making up just another political, policymaking branch of government, not as bodies restrained by the Constitution or existing laws." The editorial continues that Johnsen is "guilty" of "asking judges to impose their own policy preferences" in favor of abortion rights "against the dictates of existing constitutional law." The editorial concludes, "Someone with such contemptuous views of the Constitution should not be the Obama administration"s chief constitutional interpreter" (Washington Times, 5/21).
Endocrinology

Potential Problem-Solving In Transplant Operations From Genes That Let Creepy-Crawlies Survive A Deep Freeze

Arctic springtails (Megaphorura arctica) survive freezing temperatures by dehydrating themselves before the coldest weather sets in. Researchers writing in the open access journal BMC Genomics have identified a suite of genes involved in controlling this extreme survival mechanism. Melody Clark led a team of researchers from the British Antarctic Survey and the University of Novi-Sad, Serbia, who studied the arthropods. She said, "This is the first in-depth molecular study on the underlying cold survival mechanisms in this species. Such information is not only of interest to ecologists, but also to the medical field of cryobiology". Arctic springtails desiccate themselves in order to survive the worst of polar ice, snow and low temperatures, which can easily reach -14°C. They shrivel up into small husks until, when conditions become more favorable, they rehydrate themselves and re-emerge. This is the first study to identify the genetic basis for this physiological process. To generate the cold-induced gene expression profile of springtails, Clark and her colleagues compared gene expression in groups of the animals exposed to different environmental conditions. They showed that genes involved in a number of significant cellular processes, namely the production and mobilisation of a natural anti-freeze called trehalose, protection of cellular systems via small heat shock proteins and tissue/cellular remodeling, were activated during the cold-induced dehydration process. Genes that dominated when the animals were allowed to recover at a higher temperature, were those involved in energy production, leading to protein production and cell division. Speaking about possible implications of this research, Clark said, "This is part of a larger European project called Sleeping Beauty, which is looking at how different animals survive desiccation. Understanding how animals survive harsh cold environments will hopefully provide novel solutions for medical research and preserving tissues for transplant operations". Article: Surviving the cold: molecular analyses of insect cryoprotective dehydration in the Arctic springtail Megaphorura arctica (Tullberg). Melody S Clark, Michael A.S Thorne, Jelena Purac, Gavin Burns, Guy Hillyard, Zeljko D Popovic, Gordana Grubor-Lajsic and M Roger Worland Graeme Baldwin BioMed Central


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