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CytRx Drug Candidate INNO-206 Results In Ovarian Tumor Shrinkage In Animal Trials
CytRx Corporation (NASDAQ: CYTR), a biopharmaceutical research and development company engaged in the development of high-value human therapeutics, announced that results demonstrating that its cancer drug candidate INNO-206 caused statistically significant tumor shrinkage in an animal model of ovarian cancer have been accepted for publication in the peer-reviewed journal Investigational New Drugs. The manuscript based on this animal trial, "INNO-206, the (6-maleimidocaproyl hydrazone derivative of doxorubicin), shows superior antitumor efficacy compared to doxorubicin in different tumor xenograft models and in an orthotopic pancreas carcinoma model," was made available ahead of journal printing in electronic format in the January 8, 2009 on-line issue of Investigational New Drugs.
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Self-Monitoring And POC Diabetes Tests Reveal Potential For Significant Growth, Boosting The European Diabetes Diagnostics Market
The European diabetes diagnostics market is poised for expansion with segments such as self-monitoring and point-of-care (POC) tests offering tremendous growth potential. Heightened efforts to generate awareness about diabetes and related diagnostic tests are a key driver in market development. For instance, limited awareness about HbA1C tests is restraining the laboratory market. However, this challenge will be curtailed with more education about the test.
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Washington Times Opinion Piece, Editorial Discuss DOJ Nominee Johnsen
The Washington Times recently published an opinion piece and an editorial discussing President Obama"s nomination of Indiana University law professor Dawn Johnsen to head the Office of Legal Counsel in the Justice Department. Summaries appear below. ~ Mickey Edwards/William Sessions, Washington Times: The Senate should "act expeditiously to approve" Johnsen"s nomination because "her views on the limits of presidential power are precisely what the Constitution envisions and conservatives have long championed," Edwards, vice president of the Aspen Institute and author of "Reclaiming Conservatism," and Sessions, a partner at the law firm Holland & Knight, write in a Times opinion piece. According to the authors, Johnsen "made her views clear" on the limits of presidential power when she joined a bipartisan group of lawyers that declared that the Office of Legal Counsel should promote "presidential adherence to the rule of law." Edwards and Sessions write that Johnsen is being criticized for "being blunt, unserious and critical of presidential policies." However, these attacks are unwarranted, they write, noting that in the legal profession, "a little blunt talk to a client -- in this case, the president of the United States -- might be required." Edwards and Sessions continue, "What is needed in the Office of Legal Counsel is a person with the constitutional understanding to know that even presidents with whose politics she agrees must obey both the Constitution and federal statutes and who has the gumption to say so, even if the advice won"t be well received" (Edwards/Sessions, Washington Times, 5/21).~ Washington Times: The editorial states that Johnsen "is so radical" that 31 Republican Indiana state senators on Monday sent a letter to Sens. Evan Bayh (D-Ind.) and Dick Lugar (R-Ind.) asking them to oppose her confirmation. The Republican senators called Johnsen"s views supporting abortion rights "extremely radical" and said she often uses "harsh, sensationalizing rhetoric" in her writings on Supreme Court cases, the editorial states. According to the editorial, Johnsen"s "political advocacy shows a profound disregard for the courts" proper role" because she considers the courts "as making up just another political, policymaking branch of government, not as bodies restrained by the Constitution or existing laws." The editorial continues that Johnsen is "guilty" of "asking judges to impose their own policy preferences" in favor of abortion rights "against the dictates of existing constitutional law." The editorial concludes, "Someone with such contemptuous views of the Constitution should not be the Obama administration"s chief constitutional interpreter" (Washington Times, 5/21).
Oncology

Greater Risks For Patients With Heart Attacks Posed By Crowded Emergency Departments

Patients with heart attacks and other forms of chest pain are three to five times more likely to experience serious complications after hospital admission when they are treated in a crowded emergency department (ED), according to a new study published in the journal Academic Emergency Medicine. The authors say that this dramatic difference in rates of serious complications underscores the need for action on the part of hospital administrators, policymakers and emergency physicians to find solutions to what has been termed "a national public health problem." More than six million patients per year come to U.S. emergency departments with chest pain. "What shocked us is that these complications were not explained by what goes on in the ED, like getting aspirin or a rapid electrocardiogram," says lead author Jesse M. Pines, M.D., MBA, an assistant professor of emergency medicine and epidemiology at the Hospital of the University of Pennsylvania and a senior fellow at the Leonard Davis Institute of Health Economics. "The adverse events occurred after the patient had been admitted to the hospital. Emergency department crowding is really more of a marker of a dysfunctional hospital." The study followed 4,574 patients who were admitted to the Hospital of the University of Pennsylvania for symptoms of chest pain over an eight-year period. Ultimately, 802 were diagnosed with an acute coronary syndrome (chest pain of cardiac origin); of those, 273 had a true heart attack. There were 251 complications that occurred in the hospital after initial emergency department treatment. Complications included serious events, such as heart failure, delayed heart attacks, dangerously low blood pressure, heart arrhythmias and cardiac arrest. When the emergency department was at its highest occupancy and waiting room census, patients with acute coronary syndrome were three times more likely to experience complications in the hospital. When the "patient-hours" was highest, they were more than five times more likely to have a complication. Patient-hours is a sum of the total hours that all patients in the emergency department have been waiting. "It is a measure of real ED workload," says Pines. Patients without acute coronary syndrome, but still were sick enough to be admitted to the hospital, also had three to four times more complications at highest waiting room census and patient-hours. The authors were unable to pinpoint the exact causes for why both groups of patients had worse outcomes, but they thought that this might be due to poorer care coordination, delays in testing, and overburdened doctors and nurses in the emergency department and in the hospital. "The federal government and other payers have focused efforts on reducing unnecessary complications by refusing to pay for hospitalizations where there is a preventable cause, such as an infection from a bladder catheter or a central line," says Judd E. Hollander, M.D., the study"s senior author and professor of emergency medicine at Penn. "While it"s difficult to know what complications are truly preventable, what we do know is that crowding is preventable. But hospitals have to allocate enough res to their emergency departments so that errors are caught early and patients don"t suffer." He went on to say that the major factor that causes crowding is the boarding of admitted patients, where people spend long periods of time waiting in the emergency department after admission. "The problem is that in today"s day and age, hospitals are not held accountable for crowding and waiting times," says Hollander. Recent literature has shown that paradoxically, hospitals profit when their emergency departments are crowded because it allows more elective patients (such as pre-scheduled surgeries) to be admitted. But recently, the National Quality Forum has approved several measures of emergency department crowding, including waiting times to see a physician, overall length of stay, boarding times and left-without-being seen rates. "Once hospitals realize that their reputations will be tied to how long people wait, hospitals will have a greater incentive to reduce crowding and waiting. Making sure the emergency department isn"t crowded will certainly make patients happier, but our hope is this will make hospitals safer for everyone," says Pines. This study is published in Academic Emergency Medicine. To view the abstract for this article, please click here. Sean Wagner Wiley-Blackwell


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