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Ongoing Study Shows That Endovascular Therapy Is Associated With High Cure Rate For Childhood Eye Cancer
Expanded results of a study conducted on children with eye cancer (retinoblastoma) shows that chemotherapy delivered through endovascular (through the vessel) means not only successfully cures the cancer in a majority of cases, but achieves this cure with preserved vision. Study outcomes were presented this week at the Society of NeuroInterventional Surgery (SNIS) 6th Annual Meeting in Boca Raton, FL by lead author Pierre Gobin, Professor of Radiology in Neurosurgery and Neurology at the Weill Cornell Medical Center at New York Presbyterian Hospital in New York City.
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Neural Substrates Of Controlled And Automatic Processes Involved In Empathy For Pain
Seeing others in pain can automatically engage the brain"s empathy systems even if we are not paying attention, according to new research from Mount Sinai School of Medicine presented at the Annual Meeting of the Organization for Human Brain Mapping. The investigators showed people images of hands and feet in painful or non-painful situations while scanning the brain using magnetic resonance imaging. Under some conditions the subjects paid attention to whether the situation was painful, while in other conditions they paid attention to other aspects of the images. The results showed that a brain area called the insula responded to pain even if the subject was not paying attention to pain, while another area called the anterior cingulate cortex was important for the voluntary control of empathy for pain. The research provides a better understanding of how the social brain responds to others" pain.
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ChIP-Seq, Drosophila Targeted Mutagenesis Featured In Cold Spring Harbor Protocols
High-throughput whole-genome analysis is becoming a standard laboratory approach for investigating cellular processes. Next-generation sequencing is replacing microarrays as the technique of choice for genome-scale analysis, because it offers advantages in both sensitivity and scale. The June issue of Cold Spring Harbor Protocols features "Native Chromatin Preparation and Illumina/Solexa Library Construction" from Keji Zhao and colleagues at the National Heart, Lung and Blood Institute. The article describes sample preparation for sequencing of chromatin-immunoprecipitated DNA (ChIP-Seq) to analyze histone modification patterns using native chromatin and the Solexa/Illumina Genome Analyzer. Step-by-step instructions are given for purification of human CD4+ T cells from lymphocytes and chromatin fragmentation using micrococcal nuclease (MNase) digestion, followed by chromatin immunoprecipitation (ChIP) and construction of a library for sequencing. The article is freely available on the website for Cold Spring Harbor Protocols (http://cshprotocols.cshlp.org/cgi/content/full/2009/6/pdb.prot5237).
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Grant Encourages Protected Research Time For Medical Fellows

The American Society of Hematology (ASH) announces the five 2009 recipients of the ASH Research Training Award for Fellows, a grant that encourages junior researchers to pursue careers in academic hematology by supporting protected time to conduct research during their fellowship training. A report on the state of U.S. hematology training programs published in Blood indicates that many programs find it difficult to provide meaningful protected time for fellows to do research. Currently, research training accounts for less than 50 percent of the total educational experience in most programs. "This award will help ensure that talented trainees will be given the opportunity to perform research during their training, allowing them to develop and refine skills that will give them the best chance of contributing to significant medical advances throughout their careers". said ASH President Nancy Berliner, MD, Chief of Hematology at Brigham and Women"s Hospital in Boston, and Professor of Medicine at Harvard Medical School. The 2009 ASH Research Training Award for Fellows recipients are: - Janice M. Staber, MD, University of Iowa Children"s Hospital, Iowa City, IA - Omar I. Abdel-Wahab, MD, Memorial Sloan-Kettering Cancer Center, New York, NY - Sascha A. Tuchman, MD, Duke University Medical Center, Durham, NC - Daniel A. Pollyea, MD, Stanford University, Stanford, CA - Laura E. Hogan, MD, New York University School of Medicine, New York, NY This program provides grants of $50,000 for a one-year period to third- and fourth-year trainees. The American Society of Hematology is the world"s largest professional society concerned with the causes and treatment of blood disorders. Its mission is to further the understanding, diagnosis, treatment, and prevention of disorders affecting blood, bone marrow, and the immunologic, hemostatic, and vascular systems, by promoting research, clinical care, education, training, and advocacy in hematology. In September, ASH launched Blood: The Vital Connection , a credible online re addressing bleeding and clotting disorders, anemia, and cancer. It provides hematologist-approved information about these common blood conditions including risk factors, preventive measures, and treatment options. American Society of Hematology


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