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FDA Approves Expanded Use Of Lilly's FORTEO(R) [teriparatide (rDNA Origin) Injection] To Treat Glucocorticoid-Induced Osteoporosis
Eli Lilly and Company (NYSE: LLY) announced that the U.S. Food and Drug Administration (FDA) has approved a new use for its osteoporosis drug FORTEO((R)) [teriparatide (rDNA origin) injection] to treat osteoporosis associated with sustained, systemic glucocorticoid therapy in men and women at high risk of fracture. Glucocorticoid therapy is the most common cause of secondary osteoporosis, leading to bone loss and an increased risk for fracture.(1)
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Anterior Cingulate Cortex: Monitoring The Outcomes Of Others' Decisions
Good decision-making helps us to achieve our goals in a complicated world. Understanding which decisions are successful and which ones fail is important, and learning how other people make decisions is an important way of refining this ability. What happens in the brain when this useful information is withheld? Brain imaging researchers from Royal Holloway University of London (UK) investigated activity in the human brain at the time that volunteers interpreted the successes and failures of their own decisions, or the successes and failures of others" decisions. Crucially, when this important information was withheld, a region of the brain called the Anterior Cingulate Cortex became active in different ways depending on whether the information withheld related to decisions of the person in the scanner, or whether it related to the person that they were monitoring during the experiment. This tells us that this area works in different ways depending on whether gaps in important information relate to ourselves, or whether they relate to others".
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Teens Influenced By Movie Characters Who Smoke, Both The Good Guys And The Bad Guys
Dartmouth researchers have determined that movie characters who smoke, regardless of whether they are "good guys" or "bad guys," influence teens to try smoking. The study, published in the July 2009 issue of the journal Pediatrics, is titled "Adolescent Smoking: Who Matters More, Good Guys or Bad Guys?"
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Extracorporeal Shock Wave Therapy For The Treatment Of Chronic Pelvic Pain Syndrome In Males: A Randomised, Double-Blind, Placebo-Controlled Study

UroToday.com - At a glance one could assume that this study was solely empirical - on the contrary! Shock waves (SWs) seem to have a greater therapeutic potential than is assumed and understood today. Finally, the effect of SW cannot be explained by current models of thinking. The recently published SW model by Wess1 is a very promising and tremendous basic approach: SW could modify brain processes and pain storage patterns - both to be influenced therapeutically. We are going to follow these concepts by specific research investigating processes inside the brain during SW application. Possible reactions in the brain and changes under running Extracorporeal Shock Wave Treatment (ESWT) are presently the most promising approaches to understanding the working mechanisms of SW. We intend to apply SWs not only clinically, but also to enhance our knowledge by basic research about their therapeutic effects. The missing animal model for chronic pelvic pain syndrome (CPPS) does not contribute to simplifying the understanding of pathophysiological processes influenced by ESWT, in particular due to the fact that the knowledge about CPPS pathophysiology itself is very limited. Alteration in local perfusion is one more explanation for SW effects: We know that perfusion increases immediately after SW application. As a long-term effect, the VEGF expression in treated tissue increases. There are very conclusive investigations on ischemic heart tissue in which processes of neovascularisation have been induced by ESWT and consecutive VEGF increase. Whether there is a link from increased perfusion to pain relief is, however, still unclear. Based on most recent in vitro research we could imagine also extending this treatment to chronic bacterial prostatitis. The rationale could be several investigations proving the bactericide effects of SW. The in vitro findings could be linked with clinical effects and results in this group of patients who are still a therapeutic (and personal!) challenge to us urologists. Finally, ESWT is a typical outpatient therapy that can be offered very easily in private offices. Unfortunately, there is no reimbursement by public health services either in Germany or in Austria at the moment. Therefore, the incentive for urologists to apply ESWT for CPPS in their private offices is low. Additionally, many urologists are not aware of the fact that SW does not inevitably mean stone therapy, therefore equating to destruction. In fact, SWs have clearly shown tissue-regenerating effects. These effects are successfully used for the treatment of disorders of local perfusion, wound and fracture healing and even for cellulite. This fact must enter into urologists` awareness and the therapeutic potential of ESWT has to be understood. As a result of these changes, hopefully more urologists will consider this treatment as a viable option and recommend it to their CPPS patients. Reference: 1. Wess OJ, A neural model for chronic pain and pain relief by extracorporeal shock wave treatment. Urol Res. 2008 Dec;36(6):327-34. Written by Reinhold Zimmermann, MD as part of Beyond the Abstract on UroToday.com UroToday - the only urology website with original content written by global urology key opinion leaders actively engaged in clinical practice. To access the latest urology news releases from UroToday, go to: www.urotoday.com Copyright © 2009 - UroToday


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