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'Hijacking Mechanism' Of HIV-1' Pinpointed By McGill/JGH Researchers
Researchers at McGill University and the affiliated Lady Davis Institute for Medical Research at Montreal"s Jewish General Hospital - along with colleagues at the University of Manitoba and the University of British Columbia - may have found a chink in the armour of the human immunodeficiency virus type 1 (HIV-1), the microorganism which causes AIDS. They have pinpointed the key cellular machinery co-opted by HIV-1 to hijack the human cell for its own benefit. Their study was published in May in the Journal of Biological Chemistry.
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A Novel Approach For Treating Cognitive Impairments Identified By Animal Model For Schizophrenia
Researchers have been seeking a safe and effective way to treat cognitive impairments associated with schizophrenia by enhancing N-methyl-D-aspartate (NMDA) glutamate receptors. Functional deficits in NMDA receptors may contribute to the underlying neurobiology of this disorder. The first generation of studies trying to stimulate NMDA receptors administered large amounts of substances, like glycine or D-serine, which indirectly enhance NMDA receptor function. While there were some positive reports of efficacy, findings across studies were more inconsistent than was hoped.
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Long-Term Medtronic Device Registry First To Show How Implantable Heart Devices Work In Real-World Clinical Practice
The first results from the Medtronic Inc., (NYSE: MDT) OMNI Study were released at Heart Rhythm 2009, the annual congress of the Heart Rhythm Society, revealing that one out of six patients with implantable cardioverter-defibrillator (ICD) or cardiac resynchronization therapy-defibrillators (CRT-Ds) to prevent sudden cardiac arrest (SCA), received potentially life-saving medical therapy - either in the form of anti-tachycardia pacing (ATP) or a shock for dangerously fast heart rhythms - within a period of two years following their implant. Further, the study showed that patients received therapy at similar rates, regardless of whether they meet current medical society guidelines.
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Advances In Stem Cell Research: New Interdisciplinary Volume

In a variety of organisms, from zebrafish to fruit flies to humans, stem cells have the potential to differentiate into a variety of tissues--and, in some cases, to give rise to a complete new organism. Stem cell research, therefore, has attracted the attention of a range of biologists--reproductive biologists, cancer biologists, cell and developmental biologists, and others--who have all recognized its importance and therapeutic potential. A new book from Cold Spring Harbor Laboratory Press, Control and Regulation of Stem Cells, reviews the latest advances in stem cell research from a variety of scientific perspectives. Chapters in the book are based on presentations by world-renowned investigators at the 73rd annual Cold Spring Harbor Symposium on Quantitative Biology at Cold Spring Harbor Laboratory, which was attended by 465 scientists from more than 30 countries. "Progress in stem cell research is now extremely intense," wrote the meeting organizers, Bruce Stillman, David Stewart, and Terri Grodzicker, in the Foreword to the book. "It therefore seemed appropriate to focus the 73rd Symposium on this important and rapidly developing field, providing a unique synthesis of the exciting progress being made in the field of stem cell biology, not only for the Symposia attendees, but for a wider global audience via interviews freely available on the world wide web, and, we anticipate, for readers of these Proceedings." The book is divided into ten sections, each with 5-8 chapters on a specific topic: Germ Cells and Totipotency, Niches and Asymmetry, Embryonic Development and Multipotent Progenitors, Reprogramming Somatic Cells, Gene Expression and Transcriptional Networks, Epigenetics, Adult Stem Cells, Neural Stem Cells and Brain Tumors, Stem Cells and Cancer, and Renewal and Regeneration. The book concludes with a summary of the field, and includes a discussion of future challenges for translating basic research into clinical applications. Control and Regulation of Stem Cells is also available online (http://www.cshl-symposium.org). Libraries that purchase the hardcover edition are entitled to unlimited web access to it for their students and staff. Interviews with various speakers from the symposium are at http://meetings.cshl.edu/chats/symposium08/. Notes: About the book - Control and Regulation of Stem Cells (Cold Spring Harbor Symposia on Quantitative Biology Volume LXXIII) was published by Cold Spring Harbor Laboratory Press (© 2008). It is available in paperback (ISBN 978-087969862-1) and hardcover (ISBN 978-087969861-4), is 614 pp. in length, and includes illustrations and author and subject indexes. For additional information, please see http://www.cshlpress.com/link/conregstemp.htm. Ingrid Benirschke Cold Spring Harbor Laboratory


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