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Study Reveals A Reprogrammed Role For The Androgen Receptor In Adndrogen-independent Prostate Cancer
The androgen receptor a protein ignition switch for prostate cancer cell growth and division is a master of adaptability. When drug therapy deprives the receptor of androgen hormones, thereby halting cell proliferation, the receptor manages to find an alternate growth route. A new study by Dana-Farber Cancer Institute and Ohio State University scientists demonstrates how.
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Major Scots Study Tackles Bowel Disease In Kids
Scotland has one of the highest rates in the world of inflammatory bowel disease (IBD) and its incidence is rising among Scots children. Now researchers have begun a major Scotland wide study into IBD - which encompasses Crohn"s disease and ulcerative colitis - which afflicts around 1,000 people under 18 years old in Scotland. Their work - led by the University of Aberdeen - is being supported by a research grant of ÷£182, 235 from the Chief Scientist Office.
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Sodium Bicarbonate Appears To Slow Progression Of Chronic Kidney Disease
A daily dose of sodium bicarbonate - baking soda, already used for baking, cleaning, acid indigestion, sunburn, and more - slows the decline of kidney function in some patients with advanced chronic kidney disease (CKD), reports an upcoming study in the Journal of the American Society of Nephrology (JASN). "This cheap and simple strategy also improves patients" nutritional status, and has the potential of translating into significant economic, quality of life, and clinical outcome benefits," comments Magdi Yaqoob, MD (Royal London Hospital).
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Adolescents At Risk Of Developing Psychosis Benefit From Early And Network-Oriented Care

Family and network oriented, stress-reducing care improves level of overall functioning and mental health in adolescents at risk of developing psychosis, suggests a recent Finnish study. Jorvi Early psychosis Recognition and Intervention (JERI) project at Helsinki University Central Hospital (HUCH), Jorvi Hospital, Finland, is a project with an early intervention team for adolescents at risk of developing first-episode psychosis. As developing psychosis has been suggested to be a result of a combination of acute life stressors and trait-like vulnerability to psychosis, the intervention is based on the idea of multiprofessional, need-adapted, community-, family- and network-oriented, stress-reducing, overall functioning supporting and low-threshold care. The JERI team meets with adolescents at ages 12-20 in their natural surroundings, e.g. at school or at home, together with their parents and community co-worker, who has originally contacted the JERI team because of unclear mental health problems. The aim of the team is to recognize potential risk cases and reduce the stress level by family and network intervention. A follow-up study was performed to test how presented intervention will help adolescents at risk. Data was collected between January 2007 and May 2008. During the intervention, mean scores rose statistically significantly on overall functioning and scores on quality of life, depression, anxiety and pre-psychotic symptoms decreased statistically significantly, showing an improvement in overall functioning and mental health in adolescents at risk of developing first-episode psychosis. Adolescents did not receive other therapy or any antipsychotic medication. "JERI- intervention seems to improve level of overall functioning and support mental health in adolescents at risk of developing first-episode psychosis, even though further study with larger number of subjects, with a proper control group and with a longer follow-up time is needed", says Dr. Niklas Granē¶, the leader of the research. Results are published in the journal Early Intervention in Psychiatry. Reference: Niklas Granē¶, Marjaana Karjalainen, Jukka Anto, Arja Itkonen,Virve Edlund and Mikko Roine: An intervention to improve level of overall functioning and mental condition of adolescents at high risk of developing first-episode psychosis in Finland. Early Intervention in Psychiatry (2009; 3: 94-98) Niklas Grano, Ph.D. University of Helsinki


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